منابع مشابه
Effects of Spray Drying and Spray Chilling on Ibuprofen Dissolution
The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...
متن کاملMechanistic Understanding of Spray Drying
Purpose Spray drying is a growing technology in the pharmaceutical industry with several enabling applications in modern drug delivery. Its understanding is still vastly empirical, mainly in what relates to the particle formation step. Consequently, the design spaces are typically defined through costly experiments and their statistical interpretation. The purpose of this study is to examine th...
متن کاملSustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions.
Sustained-release of buspirone HCl (BUH) was attempted by spray drying after dissolving in two commercially available aqueous polymeric dispersions (Eudragit RS 30 D or Kollicoat SR 30 D) at five different drug:polymer ratios (1:1, 1:2, 1:3, 1:6 and 1:9). The produced spray-dried agglomerates were evaluated in terms of their particle size and morphology, production yield, encapsulation efficien...
متن کاملOptimising the Encapsulation of an Aqueous Bitter Melon Extract by Spray-Drying
Our aim was to optimise the encapsulation of an aqueous bitter melon extract by spray-drying with maltodextrin (MD) and gum Arabic (GA). The response surface methodology models accurately predicted the process yield and retentions of bioactive concentrations and activity (R² > 0.87). The optimal formulation was predicted and validated as 35% (w/w) stock solution (MD:GA, 1:1) and a ratio of 1.5:...
متن کاملModeling of Particle Formation during Spray Drying
A mathematical model for the evaporation of a single droplet, subjected to convective drying in a spray dryer was developed to study the transient phenomena of particle formation. During the constant-rate drying period, the governing equations and boundary conditions were transformed into a form containing Peclet number, Pe, as the main controlling parameter. A numerical solution was developed ...
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ژورنال
عنوان ژورنال: NIPPON SHOKUHIN KOGYO GAKKAISHI
سال: 1970
ISSN: 0029-0394
DOI: 10.3136/nskkk1962.17.1